2. Academic Validation
  3. Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia

Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia

  • Brain Res. 2005 Nov 2;1061(1):67-71. doi: 10.1016/j.brainres.2005.09.002.
Hye-Seong Park 1,  Bo Kyung Lee,  Sok Park,  Seung U Kim,  Soo Hwan Lee,  Eun Joo Baik,  Sunkyung Lee,  Kyu Yang Yi,  Sung Eun Yoo,  Chang-Hyun Moon,  Yi-Sook Jung
Affiliations

Affiliation

  • 1 Department of Physiology, School of Medicine, Ajou University, Suwon, Kyungkido 442-749, Republic of Korea.
PMID: 16225853 DOI: 10.1016/j.brainres.2005.09.002
Abstract

We investigated the effects of an Na(+)/H(+) exchanger inhibitor, sabiporide, on excitotoxicity in cultured neuronal cells and in vivo. Sabiporide attenuated glutamate- or NMDA (N-methyl-d-aspartic acid)-induced neuronal cell death. Sabiporide also reduced glutamate or NMDA-induced increase in [Ca(2+)](i). In in vivo brain ischemia model, sabiporide produced protective effects, decreasing the infarct size and edema volume. Our results suggest that sabiporide elicits neuroprotective effect both in vitro and in vivo.

Figures
Products