Sabiporide hydrochloride
Sabiporide hydrochloride is a NHE-1 inhibitor (Ki: 50 nM). Sabiporide hydrochloride has cardioprotective and neuroprotective effects. Sabiporide hydrochloride inhibits glutamate- or NMDA-induced neuronal cell death.
For research use only. We do not sell to patients.
- CAS No.: 324758-66-9
- Formula: C18H20ClF3N6O2
- Molecular Weight:444.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | IC50 |
28 nM
Compound: 1
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Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 mins
Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 mins
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[PMID: 22803959] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 324758-66-9
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Molecular Weight 444.84
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Formula C18H20ClF3N6O2
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SMILES
O=C(NC(N)=N)C1=CC=C(N2CCN(C(C3=CC=CN3)=O)CC2)C(C(F)(F)F)=C1.[H]Cl
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Synonyms
BIIB 722 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Touret N, et al. Characterization of sabiporide, a new specific NHE-1 inhibitor exhibiting slow dissociation kinetics and cardioprotective effects. Eur J Pharmacol. 2003 Jan 17;459(2-3):151-8. [Content Brief]
[2]. Park HS, et al. Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia. Brain Res. 2005 Nov 2;1061(1):67-71. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sabiporide hydrochloride Related Classifications
HY-122525A Related Classifications
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