Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia

  • Brain Res. 2005 Nov 2;1061(1):67-71. doi: 10.1016/j.brainres.2005.09.002.
Hye-Seong Park  1 ,  Bo Kyung Lee ,  Sok Park ,  Seung U Kim ,  Soo Hwan Lee ,  Eun Joo Baik ,  Sunkyung Lee ,  Kyu Yang Yi ,  Sung Eun Yoo ,  Chang-Hyun Moon ,  Yi-Sook Jung
Affiliations
  • 1. Department of Physiology, School of Medicine, Ajou University, Suwon, Kyungkido 442-749, Republic of Korea.
PMID: 16225853 DOI: 10.1016/j.brainres.2005.09.002
Abstract

We investigated the effects of an Na(+)/H(+) exchanger inhibitor, sabiporide, on excitotoxicity in cultured neuronal cells and in vivo. Sabiporide attenuated glutamate- or NMDA (N-methyl-d-aspartic acid)-induced neuronal cell death. Sabiporide also reduced glutamate or NMDA-induced increase in [CA(2+)](i). In in vivo brain ischemia model, sabiporide produced protective effects, decreasing the infarct size and edema volume. Our results suggest that sabiporide elicits neuroprotective effect both in vitro and in vivo.

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