2. Academic Validation
  3. Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor

Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor

  • Nat Med. 2005 Dec;11(12):1293-4. doi: 10.1038/nm1321.
Ronald S Veazey 1,  Martin S Springer,  Preston A Marx,  Jason Dufour,  Per Johan Klasse,  John P Moore
Affiliations

Affiliation

  • 1 Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, Louisiana 70433, USA.
PMID: 16273102 DOI: 10.1038/nm1321
Abstract

Pre-exposure oral prophylaxis with Antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10-14 d can protect a substantial proportion of macaques from vaginal Infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of Infection.

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