2. Academic Validation
  3. Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors

Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors

  • Bioorg Med Chem Lett. 2006 Jun 1;16(11):2996-9. doi: 10.1016/j.bmcl.2006.02.060.
Jin Hee Ahn 1,  Seung Jun Kim,  Woul Seong Park,  Sung Yun Cho,  Jae Du Ha,  Sung Soo Kim,  Seung Kyu Kang,  Dae Gwin Jeong,  Suk-Kyeong Jung,  Sang-Hyeup Lee,  Hwan Mook Kim,  Song Kyu Park,  Ki Ho Lee,  Chang Woo Lee,  Seong Eon Ryu,  Joong-Kwon Choi
Affiliations

Affiliation

  • 1 Bio-Organic Science Division, Korea Research Institute of Chemical Technology, 100 Jang-Dong, Yuseong-Gu, Daejeon 305-343, Republic of Korea.
PMID: 16530413 DOI: 10.1016/j.bmcl.2006.02.060
Abstract

A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9 microM in vitro and showed a reduced invasion in cell-based assay.

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