2. Academic Validation
  3. Effect of a nutritional supplement on posaconazole pharmacokinetics following oral administration to healthy volunteers

Effect of a nutritional supplement on posaconazole pharmacokinetics following oral administration to healthy volunteers

  • Antimicrob Agents Chemother. 2006 May;50(5):1881-3. doi: 10.1128/AAC.50.5.1881-1883.2006.
Angela Sansone-Parsons 1,  Gopal Krishna,  Angela Calzetta,  David Wexler,  Bhavna Kantesaria,  Mitchell A Rosenberg,  Marc A Saltzman
Affiliations

Affiliation

  • 1 Schering-Plough Research Institute, K-15-4-4455, 2015 Galloping Hill Rd., Kenilworth, NJ 07033, USA. [email protected]
PMID: 16641468 DOI: 10.1128/AAC.50.5.1881-1883.2006
Abstract

We conducted a randomized, crossover study in healthy adults to examine the effects of a nutritional supplement (Boost Plus) on posaconazole pharmacokinetics. In this study, coadministration of posaconazole with Boost Plus increased the maximum concentration of posaconazole in serum and area under the concentration-time curve from 0 to 72 h values 3.4- and 2.6-fold, respectively, compared to those for the fasted state.

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