2. Academic Validation
  3. Antidepressant principles of the roots of Polygala tenuifolia

Antidepressant principles of the roots of Polygala tenuifolia

  • J Nat Prod. 2006 Sep;69(9):1305-9. doi: 10.1021/np060207r.
Mo-Chi Cheng 1,  Chia-Ying Li,  Han-Chieh Ko,  Feng-Nien Ko,  Yun-Lian Lin,  Tian-Shung Wu
Affiliations

Affiliation

  • 1 Medical and Pharmaceutical Industry Technology and Development Center, Taipei County, Taiwan, Republic of China.
PMID: 16989524 DOI: 10.1021/np060207r
Abstract

[(125)I]RTI-55-membrane binding assay-guided fractionation and separation of a water-soluble extract of the roots of Polygala tenuifolia gave five new oligosaccharide derivatives, polygalatenosides A-E (1-5). The structures of these new oligosaccharides were established on the basis of spectroscopic evidence. Polygalatenosides A and B (1 and 2) showed significant inhibitory activity, with IC(50) values of 30.0 and 6.04 microM, respectively, in this membrane binding assay and acted as norepinephrine reuptake inhibitors through blocking norepinephrine transport.

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