2. Academic Validation
  3. Synthesis, analytical behaviour and biological evaluation of new 4-substituted pyrrolo[1,2-a]quinoxalines as antileishmanial agents

Synthesis, analytical behaviour and biological evaluation of new 4-substituted pyrrolo[1,2-a]quinoxalines as antileishmanial agents

  • Bioorg Med Chem. 2007 Jan 1;15(1):194-210. doi: 10.1016/j.bmc.2006.09.068.
Jean Guillon 1,  Isabelle Forfar,  Maria Mamani-Matsuda,  Vanessa Desplat,  Marion Saliège,  Denis Thiolat,  Stéphane Massip,  Anais Tabourier,  Jean-Michel Léger,  Benoit Dufaure,  Gilbert Haumont,  Christian Jarry,  Djavad Mossalayi
Affiliations

Affiliation

  • 1 EA 2962-Pharmacochimie, UFR des Sciences Pharmaceutiques, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. [email protected]
PMID: 17049253 DOI: 10.1016/j.bmc.2006.09.068
Abstract

An original series of 4-substituted pyrrolo[1,2-a]quinoxaline derivatives, new structural analogues of Galipea species Quinoline Alkaloids, was synthesized from various substituted 2-nitroanilines via multistep heterocyclizations and tested for in vitro antiparasitic activity upon Leishmania amazonensis and Leishmania infantum strains. Structure-activity relationships enlighten the importance of the 4-substituted alkenyl side chain on the pyrrolo[1,2-a]quinoxaline moiety to modulate the antileishmanial activity.

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