2. Academic Validation
  3. Efficient synthesis of solasodine, O-acetylsolasodine, and soladulcidine as anticancer steroidal alkaloids

Efficient synthesis of solasodine, O-acetylsolasodine, and soladulcidine as anticancer steroidal alkaloids

  • Chem Biodivers. 2007 Jan;4(1):25-31. doi: 10.1002/cbdv.200790003.
Xiaoming Zha 1,  Hongbin Sun,  Jia Hao,  Yihua Zhang
Affiliations

Affiliation

  • 1 Center for Drug Discovery, School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu Province, 210009, PR China.
PMID: 17256731 DOI: 10.1002/cbdv.200790003
Abstract

An efficient synthesis of the steroidal Alkaloids solasodine (1), O-acetylsolasodine (2), and soladulcidine (3) starting from easily available diosgenin and tigogenin in five or six steps (overall yield 25, 24, and 28%, resp.) is described. Moreover, our synthetic route provides a selective modification at C(3) of 1 and related compounds in order to carry out lead optimization on these natural antitumor steroidal Alkaloids.

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