Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest

J Nat Prod. 2007 Mar;70(3):342-6. doi: 10.1021/np060484y.

Brent J Yoder ¹, Shugeng Cao, Andrew Norris, James S Miller, Fidy Ratovoson, Jeremi Razafitsalama, Rabodo Andriantsiferana, Vincent E Rasamison, David G I Kingston

Affiliations

Affiliation

1 Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

PMID: 17326683 DOI: 10.1021/np060484y

Abstract

Bioassay-guided fractionation of an extract of the fruit of Macaranga alnifolia from Madagascar led to the isolation of four new prenylated Stilbenes, schweinfurthins E-H (1-4), and one new geranylated dihydroflavonol, alnifoliol (5). The known prenylated stilbene vedelianin (6) and the known geranylated Flavonoids bonanniol A (7), diplacol (8), bonannione A (9), and diplacone (10) were also isolated. All 10 compounds were tested for antiproliferative activity in the A2780 human ovarian Cancer cell line assay. Vedelianin (IC50 = 0.13 microM) exhibited the greatest activity among all isolates, while schweinfurthin E (IC50 = 0.26 microM) was the most potent of the new compounds.

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