2. Academic Validation
  3. Leachianone A as a potential anti-cancer drug by induction of apoptosis in human hepatoma HepG2 cells

Leachianone A as a potential anti-cancer drug by induction of apoptosis in human hepatoma HepG2 cells

  • Cancer Lett. 2007 Aug 18;253(2):224-35. doi: 10.1016/j.canlet.2007.01.025.
Crystal Sao-Fong Cheung 1,  Karen Ka-Wing Chung,  Julian Chun-Kin Lui,  Ching-Po Lau,  Po-Ming Hon,  Judy Yuet-Wa Chan,  Kwok-Pui Fung,  Shannon Wing-Ngor Au
Affiliations

Affiliation

  • 1 Department of Biochemistry, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
PMID: 17379399 DOI: 10.1016/j.canlet.2007.01.025
Abstract

The Chinese herbal medicine Radix Sophorae is widely applied as an anti-carcinogenic/ anti-metastatic agent against liver Cancer. In this study, Leachianone A, isolated from Radix Sophorae, possessed a profound cytotoxic activity against human hepatoma cell line HepG2 in vitro, with an IC(50) value of 3.4microg/ml post-48-h treatment. Its action mechanism via induction of Apoptosis involved both extrinsic and intrinsic pathways. Its anti-tumor effect was further demonstrated in vivo by 17-54% reduction of tumor size in HepG2-bearing nude mice, in which no toxicity to the heart and liver tissues was observed. In conclusion, this is the first report describing the isolation of Leachianone A from Radix Sophorae and the molecular mechanism of its anti-proliferative effect on HepG2 cells.

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