2. Academic Validation
  3. Amides with anti-platelet aggregation activity from Piper taiwanense

Amides with anti-platelet aggregation activity from Piper taiwanense

  • Fitoterapia. 2007 Sep;78(6):414-9. doi: 10.1016/j.fitote.2007.04.009.
Ih-Sheng Chen 1,  Yu-Chang Chen,  Chang-Hui Liao
Affiliations

Affiliation

  • 1 Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC. [email protected]
PMID: 17590283 DOI: 10.1016/j.fitote.2007.04.009
Abstract

Three new amides, taiwanamides A-C (1-3), and two known amides, 1-cinnamoylpyrrolidine (4) and 1-(m-methoxycinnamoyl)pyrrolide (5), have been isolated from the stem of Piper taiwanense. The structures of the new amides were determined by spectral analyses. These five amides exhibited inhibitory activity of platelet aggregation in vitro. Taiwanamide C (3) owned the most potent inhibition activity of platelet aggregation induced by collagen showing IC(50) value as 8.9 microM. Taiwanamide B (2) and 1-(m-methoxycinnamoyl)pyrrolide (5) exhibited IC(50) values of 17.3 and 17.4 microM, respectively.

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