2. Academic Validation
  3. BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development

BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development

  • Toxicol Lett. 2007 Dec 10;175(1-3):1-7. doi: 10.1016/j.toxlet.2007.08.007.
Demetrio Raldúa 1,  Patrick J Babin
Affiliations

Affiliation

  • 1 Laboratory of Environmental Toxicology (UPC), CN150, 08220 Terrassa, Spain.
PMID: 17890024 DOI: 10.1016/j.toxlet.2007.08.007
Abstract

Block lipid transport-1 (BLT-1) is a small chemical widely used to inhibit the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by scavenger receptor B, type 1 (SR-BI). This study demonstrated that BLT-1 induced in zebrafish (Danio rerio) embryos a copper-dependent phenotype with a twisted notochord, brain ventricle enlargement, and absence of melanisation, phenocopying neocuproine-treated, or calamity mutants. This finding supports an unexpected link between copper availability and SR-BI activity. The copper-chelating activity of BLT-1, revealed by its dramatic effect during embryo development, should be considered in any evaluation of the pharmacological effect of this thiosemicarbazone derivative on SR-BI activity and the potential therapeutic value of this molecule.

Figures
Products