2. Academic Validation
  3. New polyhydroxylated furostanol saponins with inhibitory action against NO production from Tupistra chinensis rhizomes

New polyhydroxylated furostanol saponins with inhibitory action against NO production from Tupistra chinensis rhizomes

  • Molecules. 2007 Aug 23;12(8):2029-37. doi: 10.3390/12082029.
Lan-Lan Xu 1,  Kun Zou,  Jun-Zhi Wang,  Jun Wu,  Yuan Zhou,  Fei-Jun Dan,  Jing Yang
Affiliations

Affiliation

  • 1 Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, PR China. [email protected]
PMID: 17960103 DOI: 10.3390/12082029
Abstract

Two furostanol saponins were obtained from the rhizomes of Tupistra chinensis Bak. Their structures were determined as 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,7alpha,22xi,26-octaol-6-one-26-O-beta-D-glucopyranoside (1) and 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,6beta,7alpha,22xi,26-nonaol-26-O-beta-D-glucopyranoside (2), on the basis of chemical and spectroscopic evidence. Both compounds displayed marked inhibitory action against NO production in rat abdomen macrophages induced by lipopolysaccharide (LPS) at 40 microg/mL.

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