2. Academic Validation
  3. Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors

Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors

  • Bioorg Med Chem Lett. 2008 Jan 1;18(1):39-43. doi: 10.1016/j.bmcl.2007.11.016.
Kiev S Ly 1,  Michael A Letavic,  John M Keith,  Jennifer M Miller,  Emily M Stocking,  Ann J Barbier,  Pascal Bonaventure,  Brian Lord,  Xiaohui Jiang,  Jamin D Boggs,  Lisa Dvorak,  Kirsten L Miller,  Diane Nepomuceno,  Sandy J Wilson,  Nicholas I Carruthers
Affiliations

Affiliation

  • 1 Johnson & Johnson Pharmaceutical Research & Development L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.
PMID: 18060777 DOI: 10.1016/j.bmcl.2007.11.016
Abstract

The synthesis and biological activity of a new series of piperazine and diazepane amides is described. The new compounds are high affinity histamine H3 ligands and serotonin reuptake inhibitors.

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