2. Academic Validation
  3. Synthesis and antiviral properties of some polyphenols related to Salvia genus

Synthesis and antiviral properties of some polyphenols related to Salvia genus

  • Bioorg Med Chem Lett. 2008 Aug 15;18(16):4736-40. doi: 10.1016/j.bmcl.2008.06.063.
Clémence Queffélec 1,  Fabrice Bailly,  Gladys Mbemba,  Jean-François Mouscadet,  Sean Hayes,  Zeger Debyser,  Myriam Witvrouw,  Philippe Cotelle
Affiliations

Affiliation

  • 1 Laboratoire de Chimie Organique et Macromoléculaire, UMR CNRS 8009, USTL, 59655 Villeneuve d'Ascq, France.
PMID: 18674899 DOI: 10.1016/j.bmcl.2008.06.063
Abstract

An efficient synthesis of the acid part of salvianolic acid E 2 is described. Compound 2 was obtained from vanillin in 10 steps and 21% overall yield. During the synthesis of 2 an unexpected 5-oxo-4b,9b-dihydroindano[1,2-b]benzofuran rac-12 was isolated. Both compounds together with the acid part of salvianolic acid D were active as HIV-1 integrase inhibitors at the submicromolar level. But they did not inhibit the replication of the virus on MT-4 cells.

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