2. Academic Validation
  3. Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl

Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl

  • Bioorg Med Chem Lett. 2008 Nov 1;18(21):5771-3. doi: 10.1016/j.bmcl.2008.09.071.
Christian O Janssen 1,  Stephanie Lim,  Ee Peng Lo,  Kah Fei Wan,  Victor C Yu,  May Ann Lee,  Siew Bee Ng,  Martin J Everett,  Antony D Buss,  David P Lane,  Rustum S Boyce
Affiliations

Affiliation

  • 1 MerLion Pharmaceuticals Pte Ltd, Medicinal Chemistry, Singapore Science Park II, Singapore 117528, Singapore.
PMID: 18845435 DOI: 10.1016/j.bmcl.2008.09.071
Abstract

The cytotoxic Macrolide kendomycin was identified as a ligand of Bcl-xL, an anti-apoptotic member of the Bcl-2 protein family. Hydrolysis-stable and protonable semi-synthetic analogues have been obtained that retain cytotoxicity and Bcl-xL binding.

Figures