2. Academic Validation
  3. Tarennanosides A-H, eight new lignan glucosides from Tarenna attenuata and their protective effect on H2O2-induced impairment in PC12 cells

Tarennanosides A-H, eight new lignan glucosides from Tarenna attenuata and their protective effect on H2O2-induced impairment in PC12 cells

  • Chem Biodivers. 2009 Apr;6(4):540-50. doi: 10.1002/cbdv.200800022.
Xian-Wen Yang 1,  Hong-Ping He,  Zhi-Zhi Du,  Hai-Yang Liu,  Ying-Tong Di,  Yan-Lin Ma,  Fang Wang,  Hua Lin,  Yi-Qing Zuo,  Ling Li,  Xiao-Jiang Hao
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P. R. China.
PMID: 19353535 DOI: 10.1002/cbdv.200800022
Abstract

Eight new lignan glucosides, tarennanosides A-H (1-8, resp.), were isolated from the whole plant of Tarenna attenuata, together with three known compounds, fernandoside, (-)-lyoniresinol, and (-)-isolariciresinol. The planar structures of new compounds were elucidated mainly by analysis of physical and spectroscopic data, and the absolute configurations were determined by acid hydrolysis as well as CD spectroscopy. Compounds 1 and 2 exhibited potent antioxidant activities against H2O2-induced impairment in PC12 cells. Preliminary mechanism study by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method showed that these two compounds could act as radical scavengers.

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