The biological functions of NF-kappaB1 (p50) and its potential as an anti-cancer target

Nuclear factor-kappaB (NF-kappaB) is a key transcriptional factor family that consists of five members in mammalian cells, including NF-kappaB1 (p50), NF-kappaB2 (p52), RelA (p65), RelB and c-Rel. NF-kappaB is implicated in multiple physiological and pathological processes, including cell proliferation and differentiation, inflammatory and immune response, cell survival and Apoptosis, cellular stress reactions and tumorigenesis. Recent studies by our group and Others have highlighted the novel functions of the p50 protein. In this review, we will focus on the regulation and functions of NF-kappaB p50.