2. Academic Validation
  3. Diketopiperazine alkaloids from a deep ocean sediment derived fungus Penicillium sp

Diketopiperazine alkaloids from a deep ocean sediment derived fungus Penicillium sp

  • Chem Pharm Bull (Tokyo). 2009 Aug;57(8):873-6. doi: 10.1248/cpb.57.873.
Lin Du 1,  Xinying Yang,  Tianjiao Zhu,  Fengping Wang,  Xiang Xiao,  Hyun Park,  Qianqun Gu
Affiliations

Affiliation

  • 1 Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao, P.R. China.
PMID: 19652417 DOI: 10.1248/cpb.57.873
Abstract

Five new diketopiperazine Alkaloids, brevicompanines D-H (3-7), together with two known analogs, allo-brevicompanine B (1) and fructigenine B (2), were isolated from a deep ocean sediment derived fungus Penicillium sp. Their structures were established by spectroscopic methods including 2D NMR and chiral HPLC analysis. Compounds 4 and 7 inhibited lipopolysaccharide (LPS)-induced nitric oxide production in BV2 microglial cells.

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