2. Academic Validation
  3. Alkaloids from the leaves of Daphniphyllum subverticillatum

Alkaloids from the leaves of Daphniphyllum subverticillatum

  • J Nat Prod. 2009 Sep;72(9):1669-72. doi: 10.1021/np9003799.
Chuan-Rui Zhang 1,  Hong-Bing Liu,  Teng Feng,  Jian-Yong Zhu,  Mei-Yu Geng,  Jian-Min Yue
Affiliations

Affiliation

  • 1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, People's Republic of China.
PMID: 19739650 DOI: 10.1021/np9003799
Abstract

Four new Alkaloids, 17-hydroxydaphnigraciline (1), subdaphnidine A (2), daphnezomine L methyl ester (3), and 11-hydroxycodaphniphylline (4), along with 24 known analogues, were isolated from the leaves of Daphniphyllum subverticillatum. The structures of 1-4 were elucidated on the basis of spectroscopic methods and from chemical evidence. Daphnilongeridine (5) showed cytotoxicity against several tumor cell lines at IC(50) values in the range 2.4-9.7 microM and against the HMEC human microvascular endothelial cell line with an IC(50) of 2.7 microM.

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