2. Academic Validation
  3. Intrinsic pressor activity of midaglizole, an alpha-2 adrenoceptor antagonist, in pithed rats

Intrinsic pressor activity of midaglizole, an alpha-2 adrenoceptor antagonist, in pithed rats

  • Jpn J Pharmacol. 1990 Aug;53(4):519-20. doi: 10.1254/jjp.53.519.
M Hirohashi 1,  K Tamura,  A Akashi
Affiliations

Affiliation

  • 1 Research Institute, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
PMID: 1976844 DOI: 10.1254/jjp.53.519
Abstract

Midaglizole (3 and 30 mg/kg, i.v.) increased blood pressure in pithed rats. The pressor response was not inhibited by intravenous prazosin (0.3 mg/kg), yohimbine (1 mg/kg), ketanserin (1 mg/kg) or diphenhydramine (5 mg/kg). Diltiazem (1 mg/kg) antagonized the hypertension. Idazoxan (10 mg/kg) also increased blood pressure, and the pressor response was inhibited by prazosin, but not by yohimbine. These results suggest that the vascular effect of midaglizole is due to a mechanism different from that of idazoxan.

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