2. GPCR/G Protein
    Neuronal Signaling
  3. Adrenergic Receptor
  4. Midaglizole

Midaglizole  (Synonyms: (±)-DG5128 free base; DG5128 free base)

Cat. No.: HY-148529 Purity: 98.28%
COA Handling Instructions

Midaglizole ((±)-DG5128 free base, DG5128 free base) is a potent α2-adrenoceptor antagonist. Midaglizole is a hypoglycemic agent. Midaglizole increases blood pressure and reduces blood glucose levels in vivo.

For research use only. We do not sell to patients.

Midaglizole Chemical Structure

Midaglizole Chemical Structure

CAS No. : 66529-17-7

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Based on 1 publication(s) in Google Scholar

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Description

Midaglizole ((±)-DG5128 free base, DG5128 free base) is a potent α2-adrenoceptor antagonist. Midaglizole is a hypoglycemic agent. Midaglizole increases blood pressure and reduces blood glucose levels in vivo[1][2][3].

In Vitro

Midaglizole stimulates insulin release with the EC50 values of 200 nM, 24 µM for rat islets and MIN6 β-cell line, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Midaglizole (3, 30 mg/kg; i.v.) increases blood pressure in rats[1].
Midaglizole (0.2, 1, 2 mg/kg; infusion) reduces blood glucose levels in dags[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 290-450 g, Male Wistar rats[1]
Dosage: 3, 30 mg/kg
Administration: I.v.
Result: Increased the blood pressure by 27 and 64 mmHg at 3, 30 mg/kg, respectively.
Animal Model: Dogs[2]
Dosage: 0.2, 1, 2 mg/kg
Administration: Superior pancreaticoduodeneal artery infusion
Result: Reduced blood glucose levels by stimulating insulin release from the pancreatic islets.
Molecular Weight

251.33

Appearance

Solid

Formula

C16H17N3
CAS No.
SMILES

C1(C(C2=CC=CC=C2)CC3=NCCN3)=NC=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : 162.5 mg/mL (646.56 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9788 mL 19.8942 mL 39.7883 mL
5 mM 0.7958 mL 3.9788 mL 7.9577 mL
10 mM 0.3979 mL 1.9894 mL 3.9788 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 16.25 mg/mL (64.66 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 16.25 mg/mL (64.66 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 16.25 mg/mL (64.66 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Midaglizole66529-17-7(±)-DG5128DG5128DG 5128DG-5128Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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