2. Academic Validation
  3. Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity

Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity

  • Bioorg Med Chem. 2009 Dec 1;17(23):8073-85. doi: 10.1016/j.bmc.2009.10.002.
Anastasia Detsi 1,  Maya Majdalani,  Christos A Kontogiorgis,  Dimitra Hadjipavlou-Litina,  Panagiotis Kefalas
Affiliations

Affiliation

  • 1 National Technical University of Athens, School of Chemical Engineering, Department of Chemical Sciences, Laboratory of Organic Chemistry, Zografou Campus, 15773 Athens, Greece. [email protected]
PMID: 19853459 DOI: 10.1016/j.bmc.2009.10.002
Abstract

A series of 2'-hydroxy-chalcones and their oxidative cyclization products, aurones, have been synthesized and tested for their antioxidant and Lipoxygenase inhibitory activity. The natural product aureusidin (31) was synthesized in high yield by a new approach. An extensive structure-relationship study was performed and revealed that several Chalcones and aurones possess an appealing pharmacological profile combining high antioxidant and lipid peroxidation activity with potent soybean LOX inhibition.

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