2. Academic Validation
  3. Production of 4-hydroxyphenyllactic acid by Lactobacillus sp. SK007 fermentation

Production of 4-hydroxyphenyllactic acid by Lactobacillus sp. SK007 fermentation

  • J Biosci Bioeng. 2010 Apr;109(4):369-71. doi: 10.1016/j.jbiosc.2009.10.005.
Wanmeng Mu 1,  Yu Yang,  Jianghua Jia,  Tao Zhang,  Bo Jiang
Affiliations

Affiliation

  • 1 State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu Province, P. R. China. [email protected]
PMID: 20226379 DOI: 10.1016/j.jbiosc.2009.10.005
Abstract

The production of 4-hydroxyphenyllactic acid (4-HO-PLA), a novel Antifungal compound, was studied in Lactobacillus sp. SK007 growth. When grown in MRS broth, the strain could produce 75 microg/ml HO-4-PLA, which was the highest reported so far. Tyrosine and 4-hydroxyphenylpyruvic acid (HO-4-PPA) supplements during fermentation could both increase the HO-4-PLA production yield, and the effect of HO-4-PPA on HO-4-PLA production was remarkably better than that of tyrosine. Using HO-4-PPA as substrate could effectively produce HO-4-PLA, which reached 1.26 mg/ml.

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