2. Academic Validation
  3. Identification of 2,3,6-trisubstituted quinoxaline derivatives as a Wnt2/β-catenin pathway inhibitor in non-small-cell lung cancer cell lines

Identification of 2,3,6-trisubstituted quinoxaline derivatives as a Wnt2/β-catenin pathway inhibitor in non-small-cell lung cancer cell lines

  • Bioorg Med Chem Lett. 2010 Oct 1;20(19):5900-4. doi: 10.1016/j.bmcl.2010.07.088.
Sang-Bum Lee 1,  Young In Park,  Mi-Sook Dong,  Young-Dae Gong
Affiliations

Affiliation

  • 1 Graduate School of Biotechnology, Korea University, Seoul 136701, Republic of Korea.
PMID: 20729080 DOI: 10.1016/j.bmcl.2010.07.088
Abstract

We screened 1434 small heterocyclic molecules and identified thirteen 2,3,6-trisubstituted quinoxaline derivatives that were able to inhibit the Wnt/β-catenin signal pathway and cell proliferation. In the screen, some of the hit compounds such as the ethylene group-coupled quinoxaline derivatives were shown to hold promise for use as potential small-molecule inhibitors of the Wnt/β-catenin signal pathway in non-small-cell lung Cancer cell lines.

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