2. Academic Validation
  3. Kinesin-14: the roots of reversal

Kinesin-14: the roots of reversal

  • BMC Biol. 2010 Aug 16:8:107. doi: 10.1186/1741-7007-8-107.
Robert A Cross 1
Affiliations

Affiliation

  • 1 Centre for Mechanochemical Cell Biology, Warwick University Medical School, Gibbet Hill, Coventry CV4 7AL, UK. [email protected]
PMID: 20731883 DOI: 10.1186/1741-7007-8-107
Abstract

Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to Other kinesins. Work on the still-enigmatic Kinesin-14 mechanism published in BMC Structural Biology shows that the carboxyl terminus of the motor head undergoes a dock-undock cycle, like that of plus-end-directed kinesins.

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