2. Academic Validation
  3. A new monoterpenoid glycoside from Myrica esculenta and the inhibition of angiotensin I-converting enzyme

A new monoterpenoid glycoside from Myrica esculenta and the inhibition of angiotensin I-converting enzyme

  • Chem Pharm Bull (Tokyo). 2010 Oct;58(10):1408-10. doi: 10.1248/cpb.58.1408.
Xuan Nhiem Nguyen 1,  Van Kiem Phan,  Van Minh Chau,  Huu Tai Bui,  Xuan Cuong Nguyen,  Kim Thu Vu,  Le Tuan Anh Hoang,  Sung-Hoon Jo,  Hae-Dong Jang,  Young-In Kwon,  Young Ho Kim
Affiliations

Affiliation

  • 1 College of Pharmacy, Chungnam National University, Daejeon 305–764, Korea.
PMID: 20930414 DOI: 10.1248/cpb.58.1408
Abstract

One new monoterpenoid glycoside, myresculoside (1), and eleven known compounds, were isolated from methanol extract of Myrica esculenta leaves by repeated column chromatography. The effects of these compounds on angiotensin I-converting Enzyme (ACE) inhibition were investigated. Compounds 3 and 4 showed the most potent ACE inhibition with rates of 29.97% and 25.63% at concentration of 100 µM, respectively. Compounds 5, 6, and 11 showed weak activity with inhibitory rates of 0.07-1.41% at concentration of 100 µM.

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