2. Academic Validation
  3. Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication

Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication

  • Bioorg Med Chem Lett. 2011 Mar 1;21(5):1414-8. doi: 10.1016/j.bmcl.2011.01.021.
Renato Skerlj 1,  Gary Bridger,  Ernest McEachern,  Curtis Harwig,  Chris Smith,  Alan Kaller,  Duane Veale,  Helen Yee,  Krystyna Skupinska,  Rossana Wauthy,  Letian Wang,  Ian Baird,  Yongbao Zhu,  Kate Burrage,  Wen Yang,  Michael Sartori,  Dana Huskens,  Erik De Clercq,  Dominique Schols
Affiliations

Affiliation

PMID: 21295470 DOI: 10.1016/j.bmcl.2011.01.021
Abstract

A novel series of CXCR4 antagonists were identified based on the substantial redesign of AMD070. These compounds possessed potent anti-HIV-1 activity and showed excellent pharmacokinetics in rat and dog.

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