2. Academic Validation
  3. Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors

Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors

  • Metallomics. 2011 Jun;3(6):600-8. doi: 10.1039/c1mt00017a.
John Spencer 1,  Jahangir Amin,  Samantha K Callear,  Graham J Tizzard,  Simon J Coles,  Peter Coxhead,  Matthew Guille
Affiliations

Affiliation

  • 1 School of Science, University of Greenwich at Medway, Central Avenue, Chatham, Kent, ME4 4TB, UK. [email protected]
PMID: 21359402 DOI: 10.1039/c1mt00017a
Abstract

(E)- and (Z)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-ones 1 have been structurally modified in order to explore SAR against a range of kinases. Of note is the submicromolar to low micromolar inhibition of DYRK3 and 4 by a number of complexes. Screening using Xenopus embryos showed some of the compounds to have potent antiangiogenisis activity.

Figures
Products