2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. (Z)-FeCP-oxindole

(Z)-FeCP-oxindole is a selective human vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with an IC50 value of 200 nM. (Z)-FeCP-oxindole can significantly inhibit VEGFR1 and PDGFRa or b at 10 μM. (Z)-FeCP-oxindole has some anticancer activity, acting on B16 murine melanoma lines with IC50 less than 1 μM.

For research use only. We do not sell to patients.

(Z)-FeCP-oxindole Chemical Structure

(Z)-FeCP-oxindole Chemical Structure

CAS No. : 1137967-28-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 127 In-stock
Solution
10 mM * 1 mL in DMSO USD 127 In-stock
Solid
1 mg USD 85 In-stock
5 mg USD 175 In-stock
10 mg USD 280 In-stock
25 mg USD 565 In-stock
50 mg USD 905 In-stock
100 mg USD 1450 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

(Z)-FeCP-oxindole Related Antibodies

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Description

(Z)-FeCP-oxindole is a selective human vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with an IC50 value of 200 nM. (Z)-FeCP-oxindole can significantly inhibit VEGFR1 and PDGFRa or b at 10 μM. (Z)-FeCP-oxindole has some anticancer activity, acting on B16 murine melanoma lines with IC50 less than 1 μM[1].
Molecular Weight

329.17

Formula

C19H15FeNO
CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

O=C1/C(C2=CC=CC=C2N1)=C/[C-]34[Fe+2]56789%10%11([CH-]%12[CH]8=[CH]9[CH]%10=[CH]%11%12)[CH]3=[CH]5[CH]6=[CH]74
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (151.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0379 mL 15.1897 mL 30.3794 mL
5 mM 0.6076 mL 3.0379 mL 6.0759 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0379 mL 15.1897 mL 30.3794 mL 75.9486 mL
5 mM 0.6076 mL 3.0379 mL 6.0759 mL 15.1897 mL
10 mM 0.3038 mL 1.5190 mL 3.0379 mL 7.5949 mL
15 mM 0.2025 mL 1.0126 mL 2.0253 mL 5.0632 mL
20 mM 0.1519 mL 0.7595 mL 1.5190 mL 3.7974 mL
25 mM 0.1215 mL 0.6076 mL 1.2152 mL 3.0379 mL
30 mM 0.1013 mL 0.5063 mL 1.0126 mL 2.5316 mL
40 mM 0.0759 mL 0.3797 mL 0.7595 mL 1.8987 mL
50 mM 0.0608 mL 0.3038 mL 0.6076 mL 1.5190 mL
60 mM 0.0506 mL 0.2532 mL 0.5063 mL 1.2658 mL
80 mM 0.0380 mL 0.1899 mL 0.3797 mL 0.9494 mL
100 mM 0.0304 mL 0.1519 mL 0.3038 mL 0.7595 mL
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(Z)-FeCP-oxindole Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Z)-FeCP-oxindole1137967-28-2VEGFRVascular endothelial growth factor receptorVEGFR2 inhibitorVEGFR1PDGFRa/banticancermelanomaInhibitorinhibitorinhibit

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