Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors

  • Metallomics. 2011 Jun;3(6):600-8. doi: 10.1039/c1mt00017a.
John Spencer  1 ,  Jahangir Amin ,  Samantha K Callear ,  Graham J Tizzard ,  Simon J Coles ,  Peter Coxhead ,  Matthew Guille
Affiliations
  • 1. School of Science, University of Greenwich at Medway, Central Avenue, Chatham, Kent, ME4 4TB, UK. [email protected]
PMID: 21359402 DOI: 10.1039/c1mt00017a
Abstract

(E)- and (Z)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-ones 1 have been structurally modified in order to explore SAR against a range of kinases. Of note is the submicromolar to low micromolar inhibition of DYRK3 and 4 by a number of complexes. Screening using Xenopus embryos showed some of the compounds to have potent antiangiogenisis activity.

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