2. Academic Validation
  3. Synthesis, cytotoxicity and topoisomerase inhibition properties of multifarious aminoalkylated indeno[1,2-c]isoquinolin-5,11-diones

Synthesis, cytotoxicity and topoisomerase inhibition properties of multifarious aminoalkylated indeno[1,2-c]isoquinolin-5,11-diones

  • Bioorg Med Chem Lett. 2011 Apr 15;21(8):2259-63. doi: 10.1016/j.bmcl.2011.02.106.
Gang Ahn 1,  Nadège Schifano-Faux,  Jean-François Goossens,  Brigitte Baldeyrou,  Axel Couture,  Pierre Grandclaudon,  Amélie Lansiaux,  Adina Ryckebusch
Affiliations

Affiliation

  • 1 EA CMF 4478, Université Lille 1-Lille Nord de France, Bat C3(2), Cité Scientifique, 59655 Villeneuve d'Ascq Cedex, France. [email protected]
PMID: 21439821 DOI: 10.1016/j.bmcl.2011.02.106
Abstract

A number of mono- or diaminoalkylated indeno[1,2-c]isoquinolin-5,11-diones analogs of 1 were synthesized and evaluated for their DNA binding affinities, Topoisomerase inhibition properties and antiproliferative activities against human Cancer cell lines (HL60). Impact of the side chain connected to the aromatic D ring and to the N6 lactam position on the biological profile will be discussed.

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