2. Academic Validation
  3. Inhibitory activity of Plantago major L. on angiotensin I-converting enzyme

Inhibitory activity of Plantago major L. on angiotensin I-converting enzyme

  • Arch Pharm Res. 2011 Mar;34(3):419-23. doi: 10.1007/s12272-011-0309-7.
Nguyen Xuan Nhiem 1,  Bui Huu Tai,  Phan Van Kiem,  Chau Van Minh,  Nguyen Xuan Cuong,  Nguyen Huu Tung,  Vu Kim Thu,  Trinh Nam Trung,  Hoang Le Tuan Anh,  Sung-Hoon Jo,  Hae-Dong Jang,  Young-In Kwon,  Young Ho Kim
Affiliations

Affiliation

  • 1 College of Pharmacy, Chungnam National University, Daejeon, Korea.
PMID: 21547673 DOI: 10.1007/s12272-011-0309-7
Abstract

Eight compounds were isolated from methanol extract of Plantago major L. leaves and investigated for their ability to inhibit angiotensin I-converting enzyme activity. Among them, compound 1 showed the most potent inhibition with rate of 28.06 ± 0.21% at a concentration of 100 μM. Compounds 2 and 8 exhibited weak activities. These results suggest that compound 1 might contribute to the ability of P. major to inhibit the activity of angiotensin I- converting enzyme.

Figures
Products