Tumor associated myelopoiesis inhibiting factors

The best characterized hemopoietic growth inhibitors in myeloid leukemias are leukemia associated inhibitor (LAI) and leukemia inhibitory activity (LIA). Both are normal cell products overproduced in leukemia. LIA is identical to acid isoferritin and LAI is not identical to LIA. They act in different ways to inhibit normal stem cell growth. The over-production of these putative normal regulators may explain the suppression of normal hemopoiesis typical of myeloid leukemias. Modulation of the production and the action of LAI and LIA therefore have potential therapeutic value in leukemia.