2. Academic Validation
  3. Cytotoxic alkaloids from Fusarium incarnatum associated with the mangrove tree Aegiceras corniculatum

Cytotoxic alkaloids from Fusarium incarnatum associated with the mangrove tree Aegiceras corniculatum

  • J Nat Prod. 2012 Apr 27;75(4):617-21. doi: 10.1021/np2008544.
Ling Ding 1,  Hans-Martin Dahse,  Christian Hertweck
Affiliations

Affiliation

  • 1 Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstrasse 11a, 07745 Jena, Germany.
PMID: 22439674 DOI: 10.1021/np2008544
Abstract

Several unusual Alkaloids, N-2-methylpropyl-2-methylbutenamide (1), 2-acetyl-1,2,3,4-tetrahydro-β-carboline (2), fusarine (3), fusamine (4), and 3-(1-aminoethylidene)-6-methyl-2H-pyran-2,4(3H)-dione (5), were isolated from the culture broth of Fusarium incarnatum (HKI0504), an endophytic fungus of the mangrove plant Aegiceras corniculatum. Compounds 2, 4, and 5 exhibit weak antiproliferative and cytotoxic activities against HUVEC, K-562, and HeLa human cell lines, respectively.

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