2. Academic Validation
  3. Leishmania virulence factors: focus on the metalloprotease GP63

Leishmania virulence factors: focus on the metalloprotease GP63

  • Microbes Infect. 2012 Dec;14(15):1377-89. doi: 10.1016/j.micinf.2012.05.014.
Martin Olivier 1,  Vanessa Diniz Atayde,  Amandine Isnard,  Kasra Hassani,  Marina Tiemi Shio
Affiliations

Affiliation

  • 1 Department of Medicine, The Research Institute of the McGill University Health Centre, Faculty of Medicine, McGill University, Montréal, Québec, Canada. [email protected]
PMID: 22683718 DOI: 10.1016/j.micinf.2012.05.014
Abstract

Parasites of Leishmania genus have developed elegant strategies permitting them to evade the innate immune response upon their initial interaction with macrophages. Their capacity to dodge the induction of macrophages microbicidal functions was found to correlate with the alteration of several signalling pathways regulating those latter. In this review, the role of the Leishmania GP63 as a critical virulence factor influencing macrophage physiology will be discussed.

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