2. Academic Validation
  3. Preparation and antitumor activity of bFGF-mediated active targeting doxorubicin microbubbles

Preparation and antitumor activity of bFGF-mediated active targeting doxorubicin microbubbles

  • Drug Dev Ind Pharm. 2013 Nov;39(11):1712-9. doi: 10.3109/03639045.2012.730527.
Yan Wu 1,  Cui-Tao Lu,  Wen-Feng Li,  Chang-Zheng Sun,  Wei Yang,  Yi Zhang,  Zheng-Xing Su,  Yan Zhang,  Hong-Xing Fu,  Pin-Tong Huang,  Hai-Feng Lv,  Dan-Dan Dai,  Xing Li,  Guang-Yong Lin,  Song-Mei Luo,  Ying-Zheng Zhao
Affiliations

Affiliation

  • 1 Department of Pharmacy, General Hospital of the Air Force , Beijing China.
PMID: 23062067 DOI: 10.3109/03639045.2012.730527
Abstract

Characterization and antitumor activity of basic fibroblast growth factor-mediated active targeting doxorubicin microbubbles (bFGF-DOX-MB) were investigated. Pluronic F68 with chemical conjugation of doxorubicin (DOX-P) and peptide KRTGQYKLC-conjugated DSPE-PEG2000 were prepared. bFGF-DOX-MB had a normal distribution of particle size, with average particle size of 2.7 μm. Using A549 mouse model, bFGF-DOX-MB combined ultrasound showed the best inhibition effect on tumor volume growth among all the test groups. Similar conclusion was obtained from experimental measurements of tumor weight change and blood cell count. From the results, chemotherapeutic drug inhibition on tumor growth could be enhanced by local ultrasound combined with active targeting bFGF-DOX-MB, which might provide a potential application for ultrasound-mediated chemotherapy.

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