2. Academic Validation
  3. A new antibacterial denitroaristolochic acid from the tubers of Stephania succifera

A new antibacterial denitroaristolochic acid from the tubers of Stephania succifera

  • J Asian Nat Prod Res. 2013;15(3):315-8. doi: 10.1080/10286020.2012.762641.
De-Lan Yang 1,  Wen-Li Mei,  Yan-Bo Zeng,  Zhi-Kai Guo,  Dai-Jing Wei,  Shou-Bai Liu,  Qing-Huang Wang,  Hao-Fu Dai
Affiliations

Affiliation

  • 1 National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou 57110 , China.
PMID: 23418880 DOI: 10.1080/10286020.2012.762641
Abstract

A new denitroaristolochic acid, demethylaristofolin C (1), together with six known Alkaloids, crebanine N-oxide (2), (-)-sukhodianine-β-N-oxide (3), palmatine (4), corydalmine (5), dehydrocorydalmine (6), and corynoxidine (7), was isolated from the tubers of Stephania succifera. The structure of demethylaristofolin C was elucidated by spectroscopic techniques (UV, IR, 1D, and 2D NMR) and HR-ESI-MS analyses. These compounds exhibited Antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains in different degrees.

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