2. Academic Validation
  3. Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probe

Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probe

  • Angew Chem Int Ed Engl. 2013 Apr 22;52(17):4641-4. doi: 10.1002/anie.201300841.
Megan K Thorson 1,  Tomas Majtan,  Jan P Kraus,  Amy M Barrios
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA.
PMID: 23512751 DOI: 10.1002/anie.201300841
Abstract

Buzzing with activity: A hydrogen sulfide selective fluorogenic probe, 7-azido-4-methylcoumarin (AzMC), serves as a highly sensitive assay for cystathionine β-synthase activity, and is suitable for the high-throughput discovery of novel Enzyme inhibitors.

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