2. Academic Validation
  3. Osteoprotegerin: multiple partners for multiple functions

Osteoprotegerin: multiple partners for multiple functions

  • Cytokine Growth Factor Rev. 2013 Oct;24(5):401-9. doi: 10.1016/j.cytogfr.2013.06.001.
Marc Baud'huin 1,  Laurence Duplomb,  Stéphane Teletchea,  François Lamoureux,  Carmen Ruiz-Velasco,  Mike Maillasson,  Françoise Redini,  Marie-Françoise Heymann,  Dominique Heymann
Affiliations

Affiliation

  • 1 INSERM, UMR957, Nantes F-44035, France; Université de Nantes, Nantes atlantique universités, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes F-44035, France; CHU, Hôtel Dieu, Nantes, France. Electronic address: [email protected].
PMID: 23827649 DOI: 10.1016/j.cytogfr.2013.06.001
Abstract

Osteoprotegerin (OPG) is an essential secreted protein in bone turnover due to its role as a decoy receptor for the Receptor Activator of Nuclear Factor-kB ligand (RANKL) in the osteoclasts, thus inhibiting their differentiation. However, there are additional ligands of OPG that confer various biological functions. OPG can promote cell survival, cell proliferation and facilitates migration by binding TNF-related Apoptosis inducing ligand (TRAIL), glycosaminoglycans or proteoglycans. A large number of in vitro, pre-clinical and clinical studies provide evidences of OPG involvement in vascular, bone, immune and tumor biology. This review describes an overview of the different OPG ligands regulating its biological functions.

Keywords

Cell adhesion; Glycosaminoglycans; Monocytes; Osteoprotegerin.

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