2. Academic Validation
  3. Effect of Nelumbo nucifera Petal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity

Effect of Nelumbo nucifera Petal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity

  • Evid Based Complement Alternat Med. 2013;2013:145925. doi: 10.1155/2013/145925.
Chandrasekaran Chinampudur Velusami 1,  Amit Agarwal 2,  Vijayalakshmi Mookambeswaran 3
Affiliations

Affiliations

  • 1 R&D Centre, Natural Remedies Pvt. Ltd., Plot No. 5B, Veerasandra Industrial Area, 19th K.M. Stone, Hosur Road, Bangalore, Karnataka 560100, India ; Center for Bioseparation Technology, VIT University, Vellore, Tamil Nadu 632014, India.
  • 2 R&D Centre, Natural Remedies Pvt. Ltd., Plot No. 5B, Veerasandra Industrial Area, 19th K.M. Stone, Hosur Road, Bangalore, Karnataka 560100, India.
  • 3 Center for Bioseparation Technology, VIT University, Vellore, Tamil Nadu 632014, India.
PMID: 24348689 DOI: 10.1155/2013/145925
Abstract

N. nucifera is one among the important medicinal Plants assessed for its antiobesity action in various preclinical models. The present study was aimed at investigating the antiobesity effect of methanol and successive water extracts of petals of N. nucifera by studying its effect on adipogenesis, adipolysis, Lipase, serotonin (5-HT2C), cannabinoid (CNR2), melanocyte concentrating hormone (MCHR1), and melanocortin (MC4R) receptors. Both methanol and successive water extracts of N. nucifera petals had an effect on inhibition of lipid storage in adipocytes and on increasing lipolysis. N. nucifera petal methanol extract exhibited the concentration-dependent inhibitory effect on Lipase activity with an IC50 value of 47 µg/mL. N. nucifera petal extracts showed evident agonist and antagonist activity towards 5-HT2C and CNR2 receptors, respectively, while it showed no effect towards MCHR1 and MC4R receptors. Overall, methanol extract of N. nucifera petals showed better activity than successive water extract.

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