1. GPCR/G Protein Neuronal Signaling
  2. MCHR1 (GPR24)
  3. GW-803430

GW-803430 (GW-3430) is a potent and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pIC50 of 9.3. GW-803430 is orally active in an animal model of obesity.

For research use only. We do not sell to patients.

GW-803430 Chemical Structure

GW-803430 Chemical Structure

CAS No. : 515141-51-2

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10 mM * 1 mL in DMSO USD 371 In-stock
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10 mg USD 591 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

GW-803430 (GW-3430) is a potent and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pIC50 of 9.3. GW-803430 is orally active in an animal model of obesity[1].

IC50 & Target

pIC50: 9.3 (MCH R1)[1]

In Vitro

GW-803430 demonstrates a potent antagonist activity towards MCH induced MCHR1 receptor with an IC50 value of ~13 nM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GW-803430 (0.3, 3, and 15 mg/kg; oral administration; once daily) causes a sustained dose-dependent weight loss relative to vehicle controls[1].
GW-803430 is a suitable compound for its good pharmacokinetic properties (bioavailability=31%, t1/2=11 h) and brain penetration (6:1 brain:plasma concentration) in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High fat diet-induced obese AKR/J mice[1]
Dosage: 0.3, 3, and 15 mg/kg
Administration: Orally, qd,12 days
Result: Caused a sustained dose-dependent weight loss of -6.2%, -12.1%, and -13.1%, respectively, relative to vehicle controls.
Molecular Weight

481.99

Formula

C25H24ClN3O3S

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=C(C=C(C3=CC=C(Cl)C=C3)S2)N=CN1C4=CC=C(OCCN5CCCC5)C(OC)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 98.06%

References
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GW-803430 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
GW-803430
Cat. No.:
HY-11083
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