1. GPCR/G Protein
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. MCHR1 (GPR24)
    Potassium Channel
  3. MCHR1 antagonist 2

MCHR1 antagonist 2 

Cat. No.: HY-100321 Purity: 98.06%
Handling Instructions

MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM; MCHR1 antagonist 2 also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells.

For research use only. We do not sell to patients.

MCHR1 antagonist 2 Chemical Structure

MCHR1 antagonist 2 Chemical Structure

CAS No. : 863115-70-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3000 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM; MCHR1 antagonist 2 also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells[1].

IC50 & Target

IC50: 65 nM (melanin concentrating hormone receptor 1), 4.0 nM (hERG in IMR-32 cells)[1]

In Vitro

MCHR1 antagonist 2 (Compound 30) is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM. MCHR1 antagonist 2 has inhibitory effects on Ca2+ flux, and hERG, with IC50s of 196 ± 30 nM and 4.0 ± 0.8 nM, respectively, in IMR-32 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

424.42

Formula

C₂₃H₂₁FN₂O₅

CAS No.

863115-70-2

SMILES

O=C(C1=CC(C2=CC(F)=CC=C2O1)=O)NC3CCN(CC4=CC=C(OCO5)C5=C4)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (23.56 mM; ultrasonic and adjust pH to 6 with HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3562 mL 11.7808 mL 23.5616 mL
5 mM 0.4712 mL 2.3562 mL 4.7123 mL
10 mM 0.2356 mL 1.1781 mL 2.3562 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (2.36 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1 mg/mL (2.36 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1 mg/mL (2.36 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MCHR1 antagonist 2MCHR1 (GPR24)Potassium ChannelMelanin concentrating hormone receptor 1KcsAmelaninconcentratinghormonehERGIMR-32Inhibitorinhibitorinhibit

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Product Name:
MCHR1 antagonist 2
Cat. No.:
HY-100321
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