1. GPCR/G Protein
    Neuronal Signaling
  2. MCHR1 (GPR24)
  3. SNAP 94847 hydrochloride

SNAP 94847 hydrochloride 

Cat. No.: HY-107625A
Handling Instructions

SNAP 94847 hydrochloride is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (Ki= 2.2 nM, Kd=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 hydrochloride binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters.

For research use only. We do not sell to patients.

SNAP 94847 hydrochloride Chemical Structure

SNAP 94847 hydrochloride Chemical Structure

CAS No. : 1781934-47-1

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10 mM * 1 mL in DMSO USD 136 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
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10 mg USD 200 In-stock
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25 mg USD 400 In-stock
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50 mg USD 680 In-stock
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100 mg USD 1150 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

SNAP 94847 hydrochloride is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (Ki= 2.2 nM, Kd=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 hydrochloride binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters[1][3].

IC50 & Target

Ki: 2.2 nM (MCHR1); Kd: 530 pM (MCHR1)[3]

In Vivo

SNAP 94847 hydrochloride (oral gavage; 20 mg/kg; 14 days) shows an exaggerated locomotor response to acute quinpirole [treatment: F(2,19)=11.31, treatment × time: F(34,323) = 4.061], the effect of SNAP 94847 on quinpirole-evoked ambulations over the entire observation period is significant compared to the untreated animals[2].
SNAP 94847 hydrochloride (oral administration; 20 mg/kg; 21 days) in drink water, produces a significant increase in ambulation relative to untreated animals [treatment: F(3,28) = 8.971; treatment × time: F(51,476)=11.50]. shows a marked increase in locomotion is apparent after 40 min in the SNAP 94847-treated group,this effect is significant over 180 min[2].
SNAP 94847 hydrochloride (oral administration; 10 mg/kg), has a good bioavailability (59%), low plasma and blood clearances of 4.2 L/hr/kg and 3.3 L/hr/kg, respectively, and the half-life was shown to be 5.2 h in rats in a PK study[3].

Animal Model: Rat[2]
Dosage: 20 mg/kg
Administration: Oral administration; 20 mg/kg; 14 days
Result: Exhibited a exaggerated locomotor response to acute quinpirole.
Animal Model: Rat[2]
Dosage: 10 mg/kg
Administration: Oral administration; 10 mg/kg
Result: Exhibited good physicochemical properties in rats.
Molecular Weight

515.03

Formula

C₂₉H₃₃ClF₂N₂O₂

CAS No.

1781934-47-1

SMILES

Cl[H].FC1=CC(OC(C=C2)=CC=C2CN3CCC(CC3)C4=CC(NC(C(C)C)=O)=CC=C4C)=CC=C1F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SNAP 94847SNAP94847SNAP-94847MCHR1 (GPR24)Melanin concentrating hormone receptor 1AntidepressantanxiolyticanxietyInhibitorinhibitorinhibit

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SNAP 94847 hydrochloride
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