ATC0175 

ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC₅₀s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders^[1].

IC₅₀: 13.5 nM (MCH1R); >10000 nM (MCH2R)^[1].

ATC0175 shows affinity for 5-HT2B and 5-HT1A with IC₅₀s of 9.66 and 16.9 nM respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ATC0175 (1, 3, 10 mg/kg; p.o.) significantly and dose-dependently reduces immobility time, indicating antidepressant like potential^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

461.94

C₂₃H₂₆ClF₂N₅O

510733-97-8

Solid

White to light yellow

CN(C1=NC(N[C@H](CC2)CC[C@H]2NC(C(C=C3)=CC(F)=C3F)=O)=NC4=C1C=CC=C4)C.Cl

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Chaki S, Yamaguchi J, Yamada H, Thomsen W, Tran TA, Semple G, Sekiguchi Y. ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. CNS Drug Rev. 2005 Winter;11(4):341-52.  [Content Brief]