1. GPCR/G Protein
    Neuronal Signaling
  2. MCHR1 (GPR24)
  3. ATC0175

ATC0175 

Cat. No.: HY-107624
Handling Instructions

ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders.

For research use only. We do not sell to patients.

ATC0175 Chemical Structure

ATC0175 Chemical Structure

CAS No. : 510733-97-8

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Description

ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders[1].

IC50 & Target

IC50: 13.5 nM (MCH1R); >10000 nM (MCH2R)[1].

In Vitro

ATC0175 shows affinity for 5-HT2B and 5-HT1A with IC50s of 9.66 and 16.9 nM respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ATC0175 (1, 3, 10 mg/kg; p.o.) significantly and dose-dependently reduces immobility time, indicating antidepressant like potential[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

461.94

Formula

C23H26ClF2N5O

CAS No.
SMILES

CN(C1=NC(N[[email protected]](CC2)CC[[email protected]]2NC(C(C=C3)=CC(F)=C3F)=O)=NC4=C1C=CC=C4)C.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
ATC0175
Cat. No.:
HY-107624
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