1. Academic Validation
  2. Pharmacological investigations on possible role of Src kinases in neuroprotective mechanism of ischemic postconditioning in mice

Pharmacological investigations on possible role of Src kinases in neuroprotective mechanism of ischemic postconditioning in mice

  • Int J Neurosci. 2014 Oct;124(10):777-86. doi: 10.3109/00207454.2013.879869.
Amit Kumar 1 Amteshwar S Jaggi Nirmal Singh
Affiliations

Affiliation

  • 1 Pharmacology Division, Department of Pharmaceutical Sciences and Drug Research, Faculty of Medicine, Punjabi University , Patiala, Punjab , India.
Abstract

The present study has been undertaken to investigate the possible role of Src Kinases in a neuroprotective mechanism of ischemic postconditioning in mice. Bilateral carotid artery occlusion for 12 min followed by reperfusion for 24 h produced a significant increase in cerebral infarct size and neurological severity score along with impairment of memory and motor coordination. Ischemic postconditioning involving three episodes of 10 s carotid artery occlusion with intermittent reperfusion of 10 s proceeding ischemic insult of 12 min, produced a significant decrease in cerebral infarct size and neurological severity score along with reversal of ischemia-reperfusion induced impairment of memory and motor coordination. Ischemic postconditioning induced neuroprotective effects were significantly attenuated by pre-treatment of selective Src Kinase inhibitors SU-6656 (4 mg/kg i.p.) and PP1 (0.2 mg/kg i.p.). It may be concluded that the neuroprotective effect of ischemic postconditioning probably involves activation of Src Kinase pathway.

Keywords

Ischemic postconditioning; Src kinase; cerebral ischemia; neuroprotection.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-B0789
    98.05%, Src Inhibitor
    Src; FAK; Akt