2. Academic Validation
  3. Preferential accumulation of the near infrared heptamethine dye IR-780 in the mitochondria of drug-resistant lung cancer cells

Preferential accumulation of the near infrared heptamethine dye IR-780 in the mitochondria of drug-resistant lung cancer cells

  • Biomaterials. 2014 Apr;35(13):4116-24. doi: 10.1016/j.biomaterials.2014.01.061.
Yang Wang 1,  Tao Liu 1,  Erlong Zhang 1,  Shenglin Luo 1,  Xu Tan 1,  Chunmeng Shi 2
Affiliations

Affiliations

  • 1 Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, 30 Gaotanyan Road, Chongqing 400038, China.
  • 2 Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, 30 Gaotanyan Road, Chongqing 400038, China. Electronic address: [email protected].
PMID: 24529902 DOI: 10.1016/j.biomaterials.2014.01.061
Abstract

Personalized oncology significantly relies on the development of theranostic agents to integrate Cancer therapeutics and diagnostics. Current strategy for development of such multifunctional agents requires multistep chemical conjugation with Cancer specific ligands, contrast agents and therapeutic drugs. In this study, we reported a near infrared (NIR) heptamethine indocyanine dye, IR-780, which selectively accumulated in the mitochondria of drug-resistant human lung Cancer cells (A549/DR) and significantly inhibited cell growth, self-renewal and migration without the need of any chemical conjugation. IR-780 was also able to induce A549/DR cell Apoptosis by disrupting the mitochondrial function. Furthermore, IR-780 dye exhibited remarkable tumoricidal activity and inhibited tumor recurrence in mouse syngeneic Lewis lung carcinoma xenograft model. With the unique properties of targeting, near infrared imaging and inhibitive effect to the drug-resistant Cancer cells both in vitro and in vivo, IR-780 may represent a potential theranostic agent for tumor recurrence.

Keywords

Drug-resistant cancer cells; IR-780 dye; Near infrared imaging; Theranostic agents; Tumor targeting.

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