2. Academic Validation
  3. A new ursane-type triterpene, cymosic acid from Rosa cymosa

A new ursane-type triterpene, cymosic acid from Rosa cymosa

  • J Asian Nat Prod Res. 2014;16(4):422-5. doi: 10.1080/10286020.2014.885507.
Xiao-Peng Wu 1,  Xiao-Po Zhang,  Guo-Xu Ma,  Mo Han,  Mu-Die Xu,  Hai-Feng Wu,  Xiao-Yan Huang,  Zhen Huang,  Jun-Shan Yang,  Jing-Quan Yuan,  Xu-Dong Xu,  Xiao-Ming Zhong
Affiliations

Affiliation

  • 1 a College of Pharmaceutical Science, Zhejiang Chinese Medical University , Hangzhou 310053 , China.
PMID: 24597721 DOI: 10.1080/10286020.2014.885507
Abstract

A new ursane-type triterpene, cymosic acid (1) together with two known compounds, 3β,19α-dihydroxy-2-oxo-12-ursen-28-oic acid (2) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid (3), were isolated from Rosa cymosa Tratt. The structure of compound 1 was elucidated by analyzing its ¹H and ¹³C NMR, ¹H-¹H COSY, HSQC, HMBC, NOESY, and HR-ESI-MS values. The three compounds were found to display moderate inhibitory activities against nitric oxide production in lipopolysaccharide-activated macrophage cell lines, RAW 264.7 cells.

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