2. Academic Validation
  3. Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr

Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr

  • Fitoterapia. 2014 Jun:95:34-41. doi: 10.1016/j.fitote.2014.02.018.
Sheng-Zhuo Huang 1,  Xuan Zhang 2,  Qing-Yun Ma 3,  Hua Peng 4,  Yong-Tang Zheng 2,  Jiang-Miao Hu 4,  Hao-Fu Dai 3,  Jun Zhou 5,  You-Xing Zhao 6
Affiliations

Affiliations

  • 1 Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
  • 2 Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650204, PR China.
  • 3 Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
  • 4 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
  • 5 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China. Electronic address: [email protected].
  • 6 Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China. Electronic address: [email protected].
PMID: 24613801 DOI: 10.1016/j.fitote.2014.02.018
Abstract

Three tigliane-type Diterpenoids named excoecafolins A-C and two daphnane-type Diterpenoids named excoecafolins D and E, together with 13 known compounds, were isolated from the EtOAc extract of Excoecaria acerifolia Didr. Their structures were elucidated through the analysis of the spectroscopic data. The anti-HIV-1 activity evaluation of five of these compounds showed that four possessed moderate anti-HIV-1 activities with EC50 0.258, 0.036, 0.046, and 0.978 μM, SI >1,836.9, 431.1, 298.7, and >503.7, respectively. Additionally, the chemotaxonomic issue of the affinity correlation between Thymelaeceae and Euphorbiaceae is discussed based on the isolates.

Keywords

4-O-methyl-TPA (PubChem CID 72292); Anti-HIV-1; Chemotaxonomy; Euphorbiaceae; Excoecafolin; Excoecaria acerifolia; caryolanel,9β-diol (PubChem CID 44559977); catechin (PubChem CID 9064); daphneticin (PubChem CID 158341); dapneolon (PubChem CID 5316300); excoecariatoxin (PubChem CID 6442008); schisanwilsonene A (PubChem CID 56671370).

Figures
Products